The University Physicians’ Foundation Inc. was organized to establish a medical school in Dasmariñas, Cavite, in support of the then government’s policy of dispersing educational facilities outside the capital city and encouraging the establishment of medical schools in various regions of the country to ensure the delivery of quality health care in the regions. 

The Foundation secured an additional 1.2 hectares of property, paving the way for the construction of a new 100-bed hospital. 

The inauguration of the University Medical Center (UMC), a distinguished four-storey teaching hospital boasting 100 beds, marked a significant milestone. Dr. Paulo Campos entrusted the administration of the hospital to the Sisters of St. Paul of Chartres.

The ownership of the University Medical Center transitioned to De La Salle University, prompting the hospital's rebranding as De La Salle University Medical Center (DLSUMC).

DLSUMC furthered its expansion efforts with the inauguration of its second building, aptly named in honor of Mr. Raul Wu, a generous donor from Hong Kong. This expansion boosted the hospital's bed capacity to 150. Additionally, a newly established 22-bed pediatric ward, complete with pediatric and neonatal intensive care units, was unveiled, enhancing the hospital's capabilities to provide comprehensive care for young patients.

DLSUMC was certified the “Best Tertiary Level Hospital in Region IV” based on the services rendered and the number of staff and existing facilities.

DLSUMC expanded its reach by acquiring a satellite hospital in Alfonso, Cavite, extending its quality healthcare services to the surrounding community and beyond.

UNICEF honored the hospital with the prestigious designation of a Mother-Baby Friendly Hospital, recognizing its steadfast commitment to promoting breastfeeding initiatives and fostering maternal and infant well-being.

DLSUMC proudly made history in October 1999 as the inaugural hospital in the Philippines to attain ISO 9001 Certification (Quality Management System) from TUV–Rheinland, solidifying its commitment to excellence in healthcare provision and patient satisfaction.

The DLSUMC Adult Immunization Center, the first of its kind in the country, was inaugurated, marking a significant milestone in healthcare advancement and public health initiatives.

DLSUMC achieved yet another milestone by obtaining ISO 14001 certification for Environmental Management System, further affirming its commitment to sustainability and environmental stewardship.

The DLSUMC Heart Institute commenced its operations on September 15, ushering in a new era of comprehensive cardiac care and innovation.

The grand unveiling of the Premier Suites and Premier Suites Lounge added a touch of elegance and luxury to DLSUMC's offerings, providing guests with an upscale experience in comfort and sophistication.

The Medical Arts Center, which houses the doctor’s clinics, Specialized Services Units, an Endoscopy Unit, and a Day Surgery Center, among other facilities, was opened and commenced operations.

DLSUMC unveiled an exciting addition to its array of services: the introduction of PET-CT Scan capabilities, marking a significant leap forward in advanced medical diagnostics.